Chemical production often involves the transfer of aggressive liquids such as acids, alkalis, solvents, and specialty chemicals. Diaphragm pumps used in chemical production are often made from corrosion-resistant materials such as PVDF, PTFE, and stainless steel. These materials allow the pumps to endure prolonged exposure to harsh chemicals without compromising performance. The diaphragm creates a complete separation between the pumping mechanism and the fluid being transferred. This makes diaphragm pumps a practical choice for transferring toxic chemicals. At the same time, it helps keep the medium isolated from external contamination throughout the transfer process.

Solid materials can present another challenge in chemical processing. Not every pumping technology is suitable for powder transfer. When fitted with a dedicated powder transfer air system, diaphragm pumps can be used to convey materials such as powdered activated carbon, nano calcium carbonate, and other fine chemical powders.